If you choose to use milk thistle, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Interactions. Other uses not proven with research have included treating malaria, mushroom poisoning, spleen or gallbladder problems, menstrual problems, liver problems (such as hepatitis B or C), and other conditions. The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA. Experts believe silymarin is the primary active ingredient of the herb. Medical research suggests that milk thistle, combined with traditional treatment, can improve diabetes. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. Milk thistle may be a useful complementary therapy to help manage type 2 diabetes. Milk Thistle Can Help Fight Symptoms of OCD - Natural Wellness Update Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Milk Thistle Tea: Benefits, Side Effects, and Dosage. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in. Milk Thistle Benefits, Side Effects and Dosage Recommendation - Dr. Axe It's also proven useful in treating skin that's been damaged by radiation during breast cancer treatment. Efficacy and safety of milk thistle preventive treatment of anti - LWW Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, Silybin and the liver: from basic research to clinical practice, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies. Milk thistle should not be used in place of medication prescribed for you by your doctor. Since milk thistle may lower blood sugar, people with diabetes should check with their doctor before taking the herb as it may make their blood sugar fall too low. National Center for Complementary and Integrative Health. This content does not have an English version. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. privacy practices. government site. Please enable it to take advantage of the complete set of features! This article looks at the evidence to, Whats the life expectancy of someone with cirrhosis of the liver? 2005 - 2023 WebMD LLC, an Internet Brands company. Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. The terms milk thistle and silymarin are often used interchangeably. Together, you can make shared, well-informed decisions. 2 skintightspandex 3 yr. ago Ya idk I've taken milk thistle for liver health and I have anxiety independent of it Nootropicsfan 3 yr. ago To ensure quality and potency in your herbal remedies, why not grow your own? Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Silibinin is one of the main flavonoids produced by milk thistle, which is reported to inhibit the inflammatory response by suppressing the nuclear factor-kappa B (NF-B) pathway. All rights reserved. Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes. https://www.nccih.nih.gov/health/milk-thistle. Milk thistle often is used as a galactalogue, a food or supplement that people who are chest feeding take to improve milk production. Follow your healthcare provider's instructions about any restrictions on food, beverages, or activity. The data is very limited, but one randomized controlled study found that mothers taking 420 mg of silymarin for 63 days produced 64% more milk than those taking a placebo (37). Milk thistle can cause an allergic reaction, including a severe, potentially life-threatening allergic reaction (anaphylaxis). Salmi, H. and Sarna, S. Effect of silymarin on chemical, functional, and morphological alterations of the liver. 12 Health Benefits Of Milk Thistle, Nutrition, & Side Effects - STYLECRAZE Milk thistle has been used as a traditional remedy for neurological conditions like Alzheimers and Parkinsons disease for over two thousand years (13). It may be effective in mild to moderate depression, but two studies reported no benefit in major depression . Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. 2016 Jul;41(7):1662-72. doi: 10.1007/s11064-016-1881-5. Milk thistle seems to have few side effects, even when taken for several years. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. BDNF-TrkB pathway mediates antidepressant-like roles of H. New insights into BDNF function in depression and anxiety. Other SSRIs on the market include Fluvoxamine (Luvox), Paroxatine (Paxil), and Sertraline (Zoloft) (3). Matutino Santos P, Pereira Campos G, Nascimento C. Neuropsychiatr Dis Treat. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. MILK THISTLE Reviews and User Ratings: Effectiveness, Ease of - WebMD Ask your doctor for advice. Zargani M, Ramirez-Campillo R, Arabzadeh E. Pflugers Arch. However, few of these claims are supported by solid evidence. Accessibility Milk Thistle & Silymarin Benefits & Uses (incl. Liver Detox) Overall, more high-quality research is needed to define the doses and clinical effects of this fascinating herb. 1982;17:51721. Natural Medicines website. However, many of the studies are small and have methodological flaws, which makes it difficult to give firm guidance on this supplement or confirm its effects (46). There is not enough scientific data to say whether or not milk thistle can help liver problems. In 2010, a double-blind, placebo-controlled study compared the effects of milk thistle to the antidepressant Prozac (fluoxetine) in treating OCD (600 milligrams of milk thistle vs 30 milligrams of Prozac daily). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). J Med Assoc Thai. 1. Effect of silymarin on chemical, functional, and morphological alterations of the liver. The nutritional content varies for each brand, so be sure to . Thats an alarmingly high percentage, leaving roughly 1.1 million people of the 2.2 million OCD sufferers in the United States seeking alternative treatment options (2) and natural remedies. Eur Endocrinol. Milk thistle. Some studies also show milk thistle may help people whose liver is damaged by industrial toxins, such as toluene and xylene. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice.
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